FEE-FOR-SERVICE
EncapS for API Productivity Optimization
Our proprietary EncapS screening platform includes classical mutagenesis to screen ~1M unique strains (producer cells) for infection against BSL1 and BSL2 pathogens including Gram-negative and Gram-positive bacteria, human and plant pathogens, and mammalian cancer cell lines (target cells). EncapS includes custom producer cell library preparation of different microbial species including gram positive and negative bacteria, yeast, and fungi, regardless of the availability of genetic tools. Mutagenized production hosts are co-encapsulated as a single microcolony along with target cells in a proprietary hydrogel nanoliter reactor “bead”. 1M beads are mixed in a single sample and monitored for quantitative, optical imaging of sensor cell killing efficiency and sorted with microfluidics to select strains with 10 - 30% improvement in productivity. The top 20 - 40 production strains are optionally isolated and evaluated at microtiter and fermentation scales at Ginkgo or returned to the partner for further evaluation.
Pricing and terms are available upon consultation and will vary based on specific requirements.
