Biologics & Peptides

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Case Study

Rapid optimization of nanobody production in Pichia yeast

We screened a 2,000-member variant library for the expression of 2 different nanobodies. We identified strains with 3-6 g/L production titers in a single round of screening.

What makes Ginkgo’s Pichia special?

10,000

Unique genetic designs tested

20x

Improvement in methanol-free expression over previous best-in-class

25 g/L

Observed recombinant protein product titer

10,000+ L

Scale of fermentation validated

Ginkgo's achievement of the first milestone has both excited and inspired us, giving us the confidence to move into the next phase of this ambitious project. This progress is a strong indicator of the potential we have to engineer biological systems that will expand the chemical space of biological medicines.

Brian Vandahl, SVP, Global Research Technologies- Novo Nordisk

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